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Unlocking FAIR Data in the Lab

Making Lab Data Accessible:

The “A” in FAIR Data Principles

by

Brian Jack

Findability is only the first step in adhering to the FAIR principles of making scientific data Findable, Accessible, Interoperable, and Reusable. After all, even if data can be found, if it can’t be accessed, it can’t be used.

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The Accessibility principle of FAIR focuses on ensuring that once data has been located, people and machines can retrieve it and the metadata that describes it, in a secure, standards-based manner.

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For labs, it doesn’t mean opening the doors to all data. It’s about balancing openness and control, allowing authorized users to access what they need while keeping sensitive information secure and compliant.

The FAIR principles behind accessibility

GO FAIR advises that accessibility is based on two underlying principles, the first of which is defined further by two additional principles:

  • A1: Data should be retrievable by standard, open communication protocols, and avoid the use of specialized or proprietary tools or communication methods, including manual human intervention.
    • A1.1: These protocols should be free and universally implementable. Common examples include web protocols such as HTTP, FTP, and SMTP.
    • A1.2: They should support authentication and authorization when required. GO FAIR says, “Ideally, accessibility is specified in such a way that a machine can automatically understand the requirements, and then either automatically execute the requirements or alert the user to the requirements.” Examples include HMAC authentication, HTTPS, FTPS, and telephone.
  • A2: Metadata should remain accessible even if the data is restricted or removed. This principle recognizes the intrinsic value of the metadata itself.

Not all data can be public, however. Because privacy, intellectual property, and regulatory rules often apply, the FAIR principles aim to make data as open as possible, but as restricted as necessary.

How a LIMS supports accessibility

A laboratory information management system (LIMS) is a powerful tool for making data accessible. Providing centralized data storage, a LIMS platform can help labs reduce silos by consolidating information in a single source of truth. Built-in role-based permissions also enable a LIMS to provide fine-grained access control, so that the right people can retrieve the right data.

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Audit trails within a LIMS allow lab operators to track who accessed what and when. This is critical for lab accountability and labs required to comply with regulations. Some LIMS also keep key metadata visible even when access to the underlying dataset is restricted to meet security and privacy standards. Each of these features helps labs meet the FAIR goal of secure, controlled accessibility inside the organization.

Where a traditional LIMS alone falls short

Traditional LIMS platforms often focus on internal workflows, so they may fall short on helping labs meet FAIR’s broader requirements. Many rely on proprietary or local access protocols rather than widely adopted, open standards, such as RESTful APIs with common authentication.

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Another challenge for labs using a traditional LIMS is that data is frequently locked behind firewalls, which makes the data invisible to collaborators outside the organization. Furthermore, long-term access may be lost if data is archived or migrated to new systems.

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In summary, while a traditional LIMS can easily make lab data accessible internally, data may not always meet the FAIR guidelines of being discoverable and retrievable across systems and over time.

Bridging the gap for truly FAIR data

To achieve fully FAIR-compliant accessibility, labs often need to pair their traditional LIMS with:

  • Open-standard APIs or data exchange protocols for machine-to-machine retrieval.
  • Secure data portals or cloud-based repositories to support access by authorized users.
  • Persistent metadata catalogs to ensure that metadata stays available, even if the original data is moved or archived.

A layered approach can help labs protect sensitive data while also keeping the data discoverable and retrievable for authorized use. For labs that do not have staff skilled in these areas, an external consultant with the right domain knowledge can help with re-evaluating current solutions and bridging any gaps.

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Alternatively, labs could use a modern informatics platform that is designed to support secure, FAIR-compliant access. Labbit, for instance, is built on FAIR data principles, providing more comprehensive FAIR coverage so labs can innovate and collaborate more easily, and future-proof their business.

Making data accessible is the only the second of the four FAIR principles

Accessibility in FAIR is about enabling secure, standards-based retrieval of both data and metadata. A traditional LIMS provides a foundation for FAIR data with centralization, permissions, and audit trails, but should be supplemented with open protocols and repositories to meet FAIR’s full vision. On the other hand, labs that use a modern informatics platform built on FAIR data principles can be confident their data meets all the FAIR principles without needing to implement additional APIs, repositories, or catalogs.

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In the next post in this series, we’ll dive into the “I” in FAIR — Interoperability — and explore how shared standards, formats, and vocabularies help data flow smoothly between systems.

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Contact us to discuss how you can make your lab data FAIR.

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